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Additional risk factors include pre-existing gastroparesis, diabetes-related autonomic neuropathy, Parkinson disease, connective tissue disorders affecting gastrointestinal motility, and concurrent use of medications known to slow gastric emptying

1a) 52,57,58,59 , and truncation of a single C-terminal amino acid residue (L585) weakens FcRn binding affinity and, consequently, reduces its in vivo plasma half-life 60,65